What is Hyaluronic Acid and What is its Essential Role for Our Skin?
Hyaluronic acid (HA) is a molecule naturally present in our body, particularly in the skin. It's a chain of sugars and amino acids with an exceptional ability to retain water – acting like a true sponge to maintain the hydration and structure of our tissues.
HA, as the main component of the extracellular matrix (ECM), plays a key role in skin aging. It is estimated that a 70 kg human body contains as much as 15 g of HA in the form of sodium hyaluronate, with more than half of the HA reserves located in the skin [1].
Long used in cosmetics, it offers various benefits, from deep hydration to fighting signs of aging. HA's effectiveness largely depends on its molecular weight, which allows for targeted actions [2].
How Do Different Forms of Hyaluronic Acid Work for Optimal Results?
For a complete and targeted action, advanced formulas often incorporate a complex of hyaluronic acids with distinct properties. Helena Rubinstein has chosen to associate 5 different types of HA in Replasty Pro Filler.
- High Molecular Weight HA (>1000kDa): Acts on the surface. It is able to retain up to 1000 times its weight in water. It forms a protective film for intense hydration and immediate smoothing, preventing water loss.
- Medium Molecular Weight HA (around 50kDa): Promotes cell cohesion and improves skin softness and elasticity.
- Low Molecular Weight HA (between 20 and 50kDa): Penetrates deeper, stimulates collagen production, provides deep hydration, and helps firm the skin.
- Acetylated HA (less than 20kDa): Modified for increased resistance (up to 13 times more durable before its breaks down within the skin). Its small size allows for deep penetration for exceptional anti-wrinkle and smoothing properties.
- Encapsulated HA: Transported beyond the skin barrier by a biocompatible polymer that has a structure close to the cellular membranes. Once in the deeper layers, it captures water and gains volume, offering an internal and long-lasting hydrating and plumping effect.
Replasty Pro-Filler offers a 10 layers deep HA filling that improve skin elasticity and tonicity. In addition, Replasty Pro Filler contains Pro-XylaneTM as well PALMITOYL TRIPEPTIDE-7 & 1 (MatrixylTM).
Pro-XylaneTM is scientifically proven to help reinforce all 3 layers of the skin (epidermis, dermo-epidermal junction and dermis). It helps epidermis maturation and stimulates collagens, glycosaminoglycans and proteoglycans, thus leading to retexturize skin, boost firmness and decrease wrinkles appearance.
PALMITOYL TRIPEPTIDE-7 & 1 (MatrixylTM) smoothe skin and unify skin texture, by boosting skin elastin.
What Concrete Results Can You Expect from an Advanced Hyaluronic Acid Serum?
Experience a uniquely transformative instant cosmetic intervention with Replasty Pro Filler. A clinical study on 50 asian women who applied the serum twice a day demonstrate significant improvements in skin appearance, visible from the first month of use, and increasing after two months. Results include a notable reduction in all types of wrinkles:
- Nasolabial fold: -21%
- Under-eye wrinkles: -23%
- Crow's feet: -16%
- Interocular wrinkles: -17%
- Forehead wrinkles: -19%
Beyond wrinkle reduction, Replasty Pro Filler also contribute to restoring skin firmness (+17%, instrumental test), improving skin elasticity and evenness (+17%); smoothing skin texture (+17%) and revealing more radiant skin (+26%).
This data highlights the transformative impact Replasty Pro Filler on overall skin quality, targeting the same benefits as skin boosters and making skin look visibly younger and revitalized.
This texturized, fresh milky emulsion has a soft feeling effect on the skin. It is ideally integrated as a treatment into your daily beauty routine as a key step to revealing the full vitality and youthfulness of your skin.
[1] Buckley, C.; Murphy, E.J.; Montgomery, T.R.; Major, I. Hyaluronic Acid: A Review of the Drug Delivery Capabilities of This Naturally Occurring Polysaccharide. Polymers 2022, 14, 3442.
[2] Chylińska, N.; Maciejczyk, M. Hyaluronic Acid and Skin: Its Role in Aging and Wound-Healing Processes. Gels 2025, 11, 281.
Audrey Gueniche
– Scientific Director
Audrey GUENICHE is a Doctor in Pharmacy and has a PhD in skin biology. She has a distinguished career of over three decades at L’Oréal in Research and Innovation. Her scientific contributions have been in the areas of topical and food supplements of skin, scalp, hair health and beauty. Audrey’s experience is extensive: from vitro to clinical trials, to open innovation and development. She has published over 130 papers in peer-reviewed journals, presented in 80 international congresses and, additionally, has been recognized and guest speaker in 50 plenary conferences. By embracing an innovative mindset, Audrey is passionate in finding new areas to promote actives and formulas, prove new claims and scientific communications, and reinvent evaluations. As HELENA RUBINSTEIN’s Scientific Director, Audrey pursues the brand’s long-standing avant-garde research and science.
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